GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7112513 | 1 | rs10750100 | chr11:116917244 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.09 | 5.59E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs10750101 | chr11:116979689 | PCSK7 | chr11:117075789-117102811:- | -0.44 | -5.48 | 7.6E-8 | Protein quantitative trait loci |
| BLCA | cis | rs10758892 | 1 | rs10758892 | chr9:7734250 | C9orf123 | chr9:7796493-7799799:- | -0.4 | -4.28 | 2.39E-5 | Myopia (pathological) |
| BLCA | cis | rs881375 | 1 | rs10760118 | chr9:123641616 | LOC253039 | chr9:123605320-123616644:+ | -0.34 | -5.89 | 8.63E-9 | Rheumatoid arthritis |
| BLCA | cis | rs881375 | 1 | rs10760121 | chr9:123647915 | LOC253039 | chr9:123605320-123616644:+ | -0.35 | -5.82 | 1.23E-8 | Rheumatoid arthritis |
| BLCA | cis | rs12220238 | 1 | rs10762582 | chr10:75968316 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.71 | 3.41E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs882367 | 1 | rs1076392 | chr17:59493008 | C17orf82 | chr17:59489112-59490641:+ | -0.19 | -4.31 | 2.09E-5 | Sitting height ratio |
| BLCA | cis | rs1077514 | 1 | rs1077514 | chr1:23766233 | TCEA3 | chr1:23707555-23751261:- | -0.3 | -4.23 | 2.88E-5 | Cholesterol, total |
| BLCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | FAM119B | chr12:58166383-58176323:+ | 0.29 | 4.54 | 7.64E-6 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | TSFM | chr12:58176536-58191367:+ | -0.36 | -6.42 | 3.97E-10 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.14 | 4.3E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | FAM119B | chr12:58166383-58176323:+ | 0.29 | 4.54 | 7.64E-6 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | TSFM | chr12:58176536-58191367:+ | -0.36 | -6.42 | 3.97E-10 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.24 | -4.14 | 4.3E-5 | Multiple sclerosis |
| BLCA | cis | rs12045807 | 1 | rs10788795 | chr1:150758047 | HORMAD1 | chr1:150670542-150693352:- | 0.4 | 4.07 | 5.67E-5 | Congenital left-sided heart lesions |